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Brand Name :
N/A
Synonyms :
2 -Propargylsuccinimidylmethyl chrysanthemate
Class :
Insecticide
Dosage Forms & Strengths
Liquid 0.2%
(off-label):
It is not for human use Inhalation LC50 in rats over dose of 1.2 mg/L indicates category III with slight toxicity potential.
Action and Spectrum
Sodium channels that are voltage-gated in nerve cell membranes that are targeted by this substance.This dis-rupts the insect neurological systems by leading to continued de-polarization of nerve cells and resulting in the repeated firing and eventual paralysis.
Frequency not defined
Braonchial or epithelial mucosal edema
Pulmonary edema
Lymphocyte infiltration
Interstitial inflammation
Nonspecific interstitial pneumonitis (NSIP)
Lung injury
Black Box Warning
None
Contraindication/Caution
Not known
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy categories:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology
It is an artificial pyrethroid pesticide that causes paralysis and ultimately death in insects by interfering with their nervous system. To cause a protracted sodium inflow and ongoing nerve cell de-polarization and its technique acts by concentrating on sodium channels that are voltage-gated in nerve cell membranes.
Pharmacodynamics
Not much data present
Pharmacokinetics
Limited infor-mation is found on the ADME
Administration
Not for human con-sumption
Patient information leaflet
Generic Name: imiprothrin
Pronounced: im-i-PRO-thrin
Why do we use imiprothrin?
It is used as a pesticide in indoor areas and used in commercial insecticide products.